I would delete any old CD installed PC Suite and download the PC Suite from Autel's website that might have newer J2534 drivers. Also see if PC suite offers a way that you can update the Autel J2534 model you have
What car are you working on, GM, Ford, Chysler? Chrysler downloads the calibration file to the wrong path for the 2009 and older cars with Windows 10. You have to move the file to the correct directory.